Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fraction

Fanny Rahardja

Abstract


Objective : The research objective was to evaluate the phytochemical compounds, the
antioxidant and anti-malarial activity of green tea extract and its fraction.
Methods : The antioxidant activity were measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH)
scavenging activity used in vitro laboratories prospective experimental design and completely
randomized design, using ethanol extract, hexane, ethyl acetate, butanol fraction, and water
fraction of green tea in 7 levels of concentration compared to epicatechin (EC). The data were
analyzed using linear regression analysis, and were continued by determined Inhibitory
Concentration50 (IC50). The anti-malarial activity of green tea fractions were compared to
artemisinin. The data were analyzed using probit analysis, and were continued by determined
IC50 .
Result: The results showed that the highest antioxidant activity (IC50) was the fraction of ethyl
acetate 2,184 μg/ml. The anti-malarial activity IC50of water and ethyl acetate fraction, ethanol
extract and butanol fraction were 0,000090 μg/mL,0,003 μg/mL, 0,006 μg/mL, 0,011 μg/ml
respectively.
Conclusion : Extract and fractions of green tea have potential anti-malarial and antioxidant
properties.

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