Investigation of testicular germ cell tumor on Cryptoorchidism with Hypospadia and Ambigous Genitalia

Amalia setyawati


Objective: To identify germ cell malignancies and carcinoma in situ (CIS) in the gonads of high risk patients
with cryptorchidism and hypospadias (DSD cases) in Semarang as well as the frequency of OCT3/4 presence in
the case of germ cell malignancy.
Methods: Specimens were examined for routine histopathology H&E staining. Immunohistochemistry staining
was performed using antibody OCT3/4 and SCF to evaluate germ cells maturity and its progress toward
malignancies as well as its precursor lesion (CIS/GB).
Result: We collected 33 specimens, however only 27 samples which qualified with categorization of Germ
Tumor. Stage of differentiation tissue was varied categorized ranging from ovary, sex cord (tubae or funiculars).
There were 7/26 samples with malignancies and precursor lesion.
Conclusion: Genetic and environmental factors involve in the indirect role in the establishment of proper
micro-environment for delayed maturation, transformation and progression of early germ cells. OCT3/4
immunostaining is a promising and useful tool in managing patients known to be at high risk for the
development of invasive GCTs.

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